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In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. Originally released in August 2023, the episode covers...
Ben Horowitz discusses critical leadership lessons from building companies, emphasizing that individual founders can change the world through decisive action. He explores the difference between wartime and peacetime CEOs, defining culture as a set of actions rather than beliefs, and explains why mandatory cultural assimilation is essential as companies scale. The conversation covers how bio/healthcare innovation differs from traditional tech due to dramatically harder distribution and innovation challenges, and closes with advice on approaching AI transformation.
Ben challenges the conventional wisdom that cultural forces drive history, arguing that individual founders make critical differences. He shares the story of how Kip Hickman secured the Internet with SSL in three months at Netscape, preventing Microsoft from creating a proprietary network with transaction fees. Without this individual effort, the open Internet might not exist.
Ben highlights Toussaint Louverture as a surprising historical leader who led the only successful slave revolt in history by merging European and slave cultures. Toussaint learned European culture, built a military from a low-trust environment, and created an economy that generated more export income than the United States at the time.
Ben defines wartime leadership as rapidly shifting from an old strategy built for one environment to a new strategy for a radically different reality. Using the analogy of switching from fighting the Cold War to fighting ISIS, he explains why wartime CEOs must be willing to be inconsistent and not listen to their teams who are still operating on the old plan.
Ben redefines culture using Samurai philosophy: culture is not a set of beliefs but a set of actions. He provides concrete examples of how daily behaviors - from email response times to meeting punctuality to how you treat partners - define culture more than mission statements. Abstract concepts like 'integrity' are meaningless without specific behavioral definitions.
Ben explains why culture doesn't naturally scale beyond 50 people and requires active intervention. When you hire groups from other companies, they bring their old culture by default. He emphasizes the need for mandatory cultural assimilation and daily behavioral reminders to prevent culture from slipping away as the organization grows.
Ben demonstrates that culture can be radically changed through the example of Toussaint transforming a low-trust slave culture into a high-trust military. By making rules like officers can't cheat on their wives (any commitment must be kept), Toussaint built an army that didn't pillage or rape, earning support from white women on the island over European armies.
Ben argues that culture must create competitive advantage or it's wasted effort. He contrasts Amazon's frugality culture (old doors as desks) supporting their low-price leadership strategy with Apple's high-design culture ($5,000 doorknobs at Cupertino). Culture doesn't come from one person - the whole organization must believe and enforce it.
Ben identifies the key difference between bio/healthcare and traditional tech: both distribution and innovation are dramatically harder. Distribution is 50x harder due to regulators, complex healthcare systems, hospitals, doctors, and patients. Innovation is harder because organizations built for traditional drug development can't easily adapt to AI, CRISPR, or gene therapy.
Ben shares his experience studying AI in graduate school when neural networks were considered the one part that wouldn't work. He emphasizes that with fundamental changes this large, you must run at it rather than making quick assessments. Understanding AI deeply can transform what looks like an existential threat into a massive competitive advantage.
Ben closes with a Rakim quote about 'Rent-A-Rappers' who jumped into rap when it was hot but will flip when things go bad. He draws a parallel to founders who entered startups to get rich versus those building something important. In difficult times, only founders with genuine mission stay - the rest run away.
Wartime vs Peacetime: Ben Horowitz on Leadership
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