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AI is becoming the orchestration layer inside the enterprise. In this episode of Big Ideas 2026, we explore the shift from isolated AI copilots to coordinated multi-agent systems that plan, analyze, a...
AI is evolving from isolated copilots to coordinated multi-agent orchestration layers inside enterprises. Four a16z partners explore how this shift requires extracting tacit knowledge into operational context, enables legacy system replacement through unified data and parallel workflows, creates new multiplayer collaboration interfaces with trust boundaries, and becomes defensible when AI reinforces business models by driving revenue rather than just reducing costs.
Seema Amble explains how enterprises must shift from isolated AI tools to coordinated multi-agent systems that behave like digital teams. The Fortune 500 will need to extract tacit knowledge from people's brains, documents, and actions to create shared context that enables agents to collaborate across departments with proper feedback loops and KPIs.
Angela Strange argues 2026 is the turning point where financial institutions will replace legacy systems because the risk of not changing exceeds the risk of change. Next-gen AI-native platforms unify data from legacy cores and external systems, enabling parallelized workflows and dramatically expanding software categories.
Alex Immerman describes vertical AI evolving through three phases: information retrieval, reasoning (2025), and multiplayer mode (2026). Complex work requires collaboration between multiple humans and agents with explicit trust rules, creating command center interfaces that separate autonomous execution from human review.
David Haber argues the strongest AI companies are those where AI reinforces the business model by driving revenue and outcomes, not just reducing costs. Market pull is much stronger when AI enables customers to make more money rather than just save on expenses, with defensibility coming from end-to-end workflow ownership and proprietary outcomes data.
Big Ideas 2026: The Enterprise Orchestration Layer
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